445 Higher ambient temperature contributes to extrinsic skin aging

Longterm exposure to ultraviolet radiation (UVR) and air pollution (PM2.5.) significantly contribute extrinsic skin aging. More recently, global warming has been recognized as an environmental threat human health. However, its effects on in general aging particular, are poorly understood. We examined the association between long-term mean temperature (Tmean) environmentally-induced phenotypes. initially used data of 806 women (aged 66–79 years) from German SALIA cohort study. The five-year residential Tmean other parameters at participant's residence was obtained secondary sources. Validated SCINEXA™ visual scores were assess employed ordinal multivariate logistic regression model adjusted for UVR, PM2.5, relative humidity (RH) exposure. In a sensitivity analysis we assured that our core robust. Our further showed positive significant with facial pigment spots (e.g. forehead, OR:1.74,95%CI: 1.01,2.98) coarse wrinkles under eyes, OR:5.29,95%CI: 3.15,8.87). Stratification by summer season similar higher signs. Importantly, robust against potential confounding RH. able replicate epidemiological results– following approach- independent consisting 1,500 Indian women. Thus, increasing may Accordingly, mechanistic studies found ex vivohuman models temperatures exceeding normal increased pigmentation time- dose-dependent manner. conclusion, ambient might represent previously unrecognized factor relevant